Are we armed with the right data? Pooled individual data review of biomarkers in people with severe upper limb impairment after stroke

KS Hayward; J Schmidt; KR Lohse; S Peters; J Bernhardt; NA Lannin; LA Boyd

Journal article

Are we armed with the right data? Pooled individual data review of biomarkers in people with severe upper limb impairment after stroke

KS Hayward, J Schmidt, KR Lohse, S Peters, J Bernhardt, NA Lannin, LA Boyd

Neuroimage Clinical | Published : 2017

DOI: 10.1016/j.nicl.2016.09.015

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Abstract

To build an understanding of the neurobiology underpinning arm recovery in people with severe arm impairment due to stroke, we conducted a pooled individual data systematic review to: 1) characterize brain biomarkers; 2) determine relationship(s) between biomarkers and motor outcome; and 3) establish relationship(s) between biomarkers and motor recovery. Three electronic databases were searched up to October 2, 2015. Eligible studies included adults with severe arm impairment after stroke. Descriptive statistics were calculated to characterize brain biomarkers, and pooling of individual patient data was performed using mixed-effects linear regression to examine relationships between brain bi..

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University of Melbourne Researchers

Kate Hayward Author

Julie Bernhardt Author

Related Projects (2)

RESEARCH FELLOWSHIP

Stroke affects 1 in 6 Australians and often leads to lifelong disability. This Fellowship will support A/Prof Bernhardt to: 1) complete the ..

PROMOTING UPPER LIMB RECOVERY AFTER STROKE IN PEOPLE WITH SEVERE PARESIS

Stroke survivors with severe arm disability have poor potential for functional recovery. Yet, an incomplete understanding of indicators of g..

Grants

Awarded by National Health and Medical Research Council

Funding Acknowledgements

KSH was supported by the Heart and Stroke Foundation of Canada, Michael Smith Foundation for Health Research (MSFHR) British Columbia Canada, and the National Health and Medical Research Council (NHMRC) of Australia (1088449); SP was supported by the Canadian Institutes of Health Research; JB was supported by the NHMRC of Australia (1058635); NAL was supported by the NHMRC of Australia (1112158); LAB was supported by the Canada Research Chairs (CI-SCH-01796) and MSFHR British Columbia Canada. Research affiliates (KSH, JB) of the Florey Institute of Neuroscience and Mental Health acknowledge the strong support from the Victorian Government, and in particular funding from the Operational Infrastructure Support Grant. This study was completed under funding received from the Jakeway Foundation (KSH and LB). The Jakeway Foundation had no role in writing or decision to submit the publication. LB (corresponding author) had full access to all data and takes full responsibility for the decision to submit for publication.